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Long noncoding RNAs (lncRNAs) fine-tune the epigenetic landscape. Conrad Waddington envisioned the epigenetic landscape as a series of progressively restricted ridges and valleys a cell can traverse during its differentiation. During this process, lncRNAs (here pictured as magnets) can fine-tune cell-fate specification providing a “force” that directs cellular differentiation into a specific fate.
