Table 2. Rat pharmacological data for D1 and D2 a .
Compd. | D1 | D2 |
Cl (mL min–1 kg–1) | 28 ± 5 | 29 ± 6 |
Vd (L K–1) | 0.7 ± 0.2 | 0.8 ± 0.2 |
t 1/2 (h) | 0.47 ± 0.1 | 0.5 ± 0.1 |
AUC (μM h) | 1.6 ± 0.3 | 1.5 ± 0.2 |
Cmax (μM) | 0.67 ± 0.03 | 0.6 ± 0.04 |
F (%) | 25 ± 5 | 23 ± 5 |
aData were the means of three determinations.