Figure 1.

The influence of RNA kinetic rates on RNA abundance and responsiveness. (A) Schematic representation of the RNA life cycle, governed by the kinetics rates of synthesis, processing and degradation. (B) Deterministic mathematical model of the RNA life cycle based on ordinary differential equations (ODEs), including the solution of the system at steady state. (C–L) Solutions of the ODE system following the modulation of the kinetic rates: Each example reports, for premature and mature RNA species (left) and for the kinetic rates (right), the ratio to the initial time point. Initial values are indicated within each panel.