Figure 6.

Modeling RNA dynamics without assumptions on the functional form. (A) Simulated data composed by 500 constant genes and 500 genes subject to the circadian oscillation of synthesis (top) or synthesis followed by degradation rates (bottom). (B) Chi-square goodness of fit of sigmoid or impulse models on the data sets in A using INSPEcT+ or INSPEcT−. (C) ROC analysis of the classification of synthesis (top) or synthesis and degradation rates (bottom) using INSPEcT+ or INSPEcT− with linear piecewise functions.