KEY RESOURCES TABLE.

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, Peptides, and Recombinant Proteins
High capacity cDNA Reverse Transcription kit	Applied Biosystems	Cat# 43-688-14
RNAeasy Plus Mini Kit	QIAGEN	Cat# 74134
Power SYBR Green PCR Master Mix	Applied Biosystems	Cat# 4367659
D-Glucose-6, 6-d₂	Sigma-Aldrich	Cat# 282650
L-Valine-¹⁵N	Sigma-Aldrich	Cat# 490172
Critical Commercial Assays
Ultra Sensitive Mouse Insulin ELISA	Crystal Chem	Cat# 90080
Experimental Models: Organisms/Strains
Mouse: Pp2cm^KO	Yibin Wang (UCLA)	N/A
Mouse: C57BL/6J	The Jackson Laboratory	Stock # 000664
Rat: Long Evans	Envigo, US	HsdBlu: LE
Oligonucleotides
Actb F-CTA AGG CCA ACC GTG AAA AG	Integrated DNA Technologies	N/A
Actb R-ACC AGA GGC ATA CAG GGA CA	Integrated DNA Technologies	N/A
Slc7a5 F- CTG TGT GGG TCA CTT GTT AG	Integrated DNA Technologies	N/A
Slc7a5 R- TAG GTG CTG TTA GGG TCA T	Integrated DNA Technologies	N/A
Slc7a8 F- ACT CAG ATT GTC ACC GTT AAG	Integrated DNA Technologies	N/A
Slc7a8 R- GTG GAG AAG AAG GCA AAG AG	Integrated DNA Technologies	N/A
BCDKHA F- CCG GAT TGT GAT CTG TTA CTT	Integrated DNA Technologies	N/A
BCDKHA R- CAG AAG AAG ATG ATG GGA CAC	Integrated DNA Technologies	N/A
BCAT2 F- CAA GCA ACT CCA CAT ACC TAC	Integrated DNA Technologies	N/A
BCAT2 R- ACA CCC GAA ACA TCC AAT C	Integrated DNA Technologies	N/A
Software and Algorithms
GraphPad Prism	GraphPad Software	Version 8.2.0
Other
Regular chow diet (Pp2cm^KO and WT)	Envigo Teklad	Cat# 7012
60% High Fat Diet (Pp2cm^KO and WT)	Research Diets	Cat# D12492
60% High Fat Diet + BCAA	Research Diets	Cat# D16121102
60% High Fat Diet (control for BCAA diet)	Research Diets	Cat# D16121101
45% High Fat Diet (rat studies only)	Research Diets	Cat# D03082706
Osmolite 1.0 Cal	Abbott	Cat# 64633
Ensure Plus (for liquid mixed-meal gavage)	Abbott	Cat # 57263
Accu-Chek Aviva Meter	Accu-Chek, Roche Diabetes Care	https://www.accu-chek.com
Nuclear Magnetic Resonance	EchoMRI LLC, USA	EchoMRI-900 TM
TSE PhenoMaster System	TSE Systems, Germany	https://www.tse-systems.com