Table 3.
Sensitivity of sVNT.
| 20% Cut-off | 30% Cut-off | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Category | Total | Positive (%) | Negative (%) | Sensitivity % (95% CI) |
Positive (%) |
Negative (%) |
Sensitivity % (95% CI) |
||
| All | 269 | 216 (80.3) | 53 (19.7) | 80.3 (74.9-84.8) | 207 (77.0) | 62 (23.0) | 77.0 (71.4-81.8) | ||
| dpos/dpd | |||||||||
| <14 days | 92 | 69 (75.0) | 23 (25.0) | 75.0 (64.7-83.2) | 68 (73.9) | 24 (26.1) | 73.9 (63.5-82.3) | ||
| ≥14 days | 177 | 147 (83.1) | 30 (16.9) | 83.1 (76.5-88.1) | 139 (78.5) | 38 (21.5) | 78.5 (71.6-84.2) | ||
| P-NT50/VNT50 | |||||||||
| <10 | 50 | 9 (18.0) | 41 (82.0) | 18.0 (9.0-31.9) | 6 (12.0) | 44 (88.0) | 12.0 (5.0-25.0) | ||
| ≥10 to <40 | 35 | 26 (74.3) | 9 (25.7) | 74.3 (56.4-86.9) | 24 (68.6) | 11 (31.4) | 68.6 (50.6-82.6) | ||
| ≥40 to <160 | 57 | 56 (98.2) | 1 (1.8) | 98.2 (89.4-99.9) | 55 (96.3) | 2 (3.7) | 96.3 (86.2-99.4) | ||
| ≥160 | 116 | 116 (100) | 0 (0) | 100 (96.0-100) | 115 (99.1) | 1 (0.9) | 99.1 (94.6-100) | ||
| ND | 11 | 9 (81.8) | 2 (18.2) | 81.8 (47.8-96.8) | 7 (63.6) | 4 (36.4) | 63.6 (31.6-87.6) | ||
| Severity <14 dpos/dpd | |||||||||
| Mild | 19 | 9 (47.4) | 10 (52.6) | 47.4 (25.2-70.5) | 9 (47.4) | 10 (52.6) | 47.4 (25.2-70.5) | ||
| Severe | 41 | 29 (70.7) | 12 (29.3) | 70.7 (54.3-83.4) | 29 (70.7) | 12 (29.3) | 70.7 (54.3-83.4) | ||
| Deceased | 20 | 20 (100) | 0 (0) | 100 (80.0-100) | 20 (100) | 0 (0) | 100 (80.0-100) | ||
| unknown | 12 | 11 (91.7) | 1 (8.3) | 91.7 (59.8-99.6) | 10 (83.3) | 2 (16.7) | 83.3 (50.9-97.1) | ||
| Severity ≥14 dpos/dpd | |||||||||
| Asymptomatic | 3 | 2 (66.7) | 1 (33.3) | 66.7 (12.5-98.2) | 2 (66.7) | 1 (33.3) | 66.7 (12.5-98.2) | ||
| Mild | 73 | 55 (75.3) | 18 (24.7) | 75.3 (63.6-84.4) | 50 (68.5) | 23 (31.5) | 68.5 (56.4-78.6) | ||
| Severe | 46 | 42 (91.3) | 4 (8.7) | 91.3 (78.3-97.2) | 41 (89.1) | 5 (10.9) | 89.1 (75.6-95.9) | ||
| ICU/Deceased | 34 | 30 (88.2) | 4 (11.8) | 88.2 (71.6-96.2) | 30 (88.2) | 4 (11.8) | 88.2 (71.6-96.2) | ||
| unknown | 21 | 18 (85.7) | 3 (14.3) | 85.7 (62.6-96.2) | 16 (76.2) | 5 (23.8) | 76.2 (52.5-90.9) | ||
DPOS, days post onset of symptoms; DPD days post diagnosis; P-NT50 pseudovirus neutralization test 50% inhibition titer; VNT50 virus neutralization test 50% inhibition titer; ND, not determined; 95% CI, 95% confidence interval.