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. 2020 Oct 25;11(12):2526–2533. doi: 10.1021/acsmedchemlett.0c00521

Table 2. Measured Activities of the 17 Compounds Tested for Inhibition of M^pro.

Compound	% Activity at 100 μM	IC₅₀(μM)
manidipine	1	4.81 ± 1.87
boceprevir	6	5.40 ± 1.53
lercanidipine	8	16.2 ± 2.94
efonidipine	18	38.5 ± 0.41
bedaquiline	28	18.7 ± 4.20
perampanel	43	100–250^a^,^b
periciazine	55	250^a
nelfinavir	64	250–600^a
tipranavir	65	>600^a
azelastine	69	20–100^a
cinnoxicam	75	>600^a
idarubicin	82	250–600^a
clofamizine	88	>600^a
talampicillin	90	250–600^a
indinavir	100	NA
cabergoline	100	NA
lapatinib	100	NA

^a

Estimate due to incomplete inhibition at 600 μM.

^b

Fluorescence of compound interfered with assay.