FIG 4.

Effect of brigatinib and crizotinib on global health status/quality of life (GHS/QoL): Time to worsening in GHS/QoL score from the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire-C30 (version 3.0) in (A) all patients, and (B) patients without prior chemotherapy. Duration of improvement in GHS/QoL score from the EORTC QoL Questionnaire-C30 (version 3.0) in (C) all patients, and (D) patients without prior chemotherapy. (*) A change of ≥ 10 points was defined as the minimal clinically meaningful deterioration. Time to worsening was defined as time from the date of random assignment to the earliest date at which the patient’s score had a ≥ 10-point deterioration from baseline. (†) A change of ≥ 10 points was defined as the minimal clinically meaningful improvement. Duration of improvement was defined as time from the date of first improvement to the date of first deterioration after the improvement. The first improvement was defined as a ≥ 10-point improvement from baseline.