Table 3.

Summary of previous/current biophysical models used to describe the principal features of L5-PCs^a

Study	Compartments	Ions	Platform	Features explained
Rapp et al., 1996	>>1000	2: 2/c; Total >>2000	NEURON	BAC firing
Larkum et al., 2004	2	2: 1/c, +IF model; Total = 2	Not reported	f-I curves
Schaefer et al., 2003	8	7: 6/c; Total = 48	NEURON	BAC firing; CF
Hay et al., 2011	196 sections; 1018 segments	8: 9/c S(1); 7/c AD(561); 1/c BD(454); Total = 4390	NEURON	BAC firing; CF; f-I curves
Bahl et al., 2012	5 sections; 14 segments	8: 1/c Ah(5); 5/c S(1); 1/c BD(1), 4/c AD(7); Total = 39	NEURON	BAC firing; f-I curves
Almog and Korngreen, 2014	153 sections; 663 segments	8: 8/c; Total = 5304	NEURON	BAC firing; CF
Chua et al., 2015	3	1: 1/c AD, + IF model; Total = 1	NEST	BAC firing
Yi et al., 2017	2	3: 2/c S(1), 1/c AD(1); Total = 3	MATLAB	f-I curves
Mäki-Marttunen et al., 2018	4 sections; 20 segments	10: 9/c S(1), 1/c BD(1); 7/c AD(5), 7/c T(2); Total = 59	NEURON	BAC firing; f-I curves; [Ca2+]i
Current study	2	7: 2/c BD/S(1), 5/c; AD/T(1); Total = 7	MATLAB	BAC firing; CF; f-I curves; [Ca2+]i; Ih effect; CSD maps

^aThe first, second, third, and fourth columns show the study, number of compartments, number of ionic channels, and the platform used to create the simulated data for each study. The fifth column lists the features that were explained by each study. The column “Ions” provides the following information: $N_s:N_c/c$, where $N_s$ and $N_c$ are the number of ionic species considered and the number of ionic channels per compartment, respectively. In some cases, the number of ionic channels per compartment depends on the regions of the neuron considered. IF, Integrated and fire model; S, soma; AD, apical dendrites; BD, basal dendrites; T, trunk; A_h, axon hillock.