Figure 2.

CBF and tau are negatively correlated in secondary gray matter-masked ADNI analyses. A, Clusters shown in blue color scale depict significant negative correlations between CBF (normalized by global gray matter CBF) and FTP SUVR across the whole group (n = 138). B, Blue clusters show significant CBF–tau correlations in the ADNI AD-MCI subgroup (n = 65). C, Significant negative CBF–tau correlations in the ADNI CN subgroup (n = 73). All analyses were covaried for age, sex, and amyloid CL (and diagnosis in A and B). For visualization purposes, average CBF and FTP SUVRs from selected significant clusters in the voxelwise analysis were extracted, adjusted for covariates, and plotted below voxelwise results. Coordinates and statistics for all significant clusters are listed in Extended Data Figure 2-1. Note: because the voxelwise statistical threshold was set at p < 0.001, the p value for each of the plots is <0.001. EC – entorhinal cortex; IPL/SPL – inferior/superior parietal lobe; SMG – supramarginal gyrus; mPFC – medial prefrontal cortex.