Figure 5.

Interactions between MoCA and CBF are stronger in amyloid⁺ individuals. Amyloid * CBF interaction effects on FTP SUVR in replication (A), and secondary GM-masked ADNI (B) analyses, split by amyloid status (amyloid⁺ on the left, amyloid^– on the right). Average CBF and FTP SUVR from significant clusters in the voxelwise analysis were entered into GLMs. Predicted FTP SUVR from the models is plotted against regional CBF (normalized by global gray matter CBF). All analyses were covaried for age, sex, diagnosis, gray matter volume, and amyloid CL. MoCA was entered as a continuous variable in the model, but for visualization purposes a median split was used to group participants into a low-MoCA group (shown in orange) and a high-MoCA group (shown in green). Detailed statistics for all MoCA * CBF/sPDGFRβ interaction terms for amyloid⁺ and amyloid^– groups are listed in Extended Data Figure 5-1. Plots for the AD-MCI subgroup of the ADNI replication cohort are displayed in Extended Data Figure 5-2. Note: the p values shown on the scatterplots is for display purposes only and is not a statistical result from the primary GLM analyses including MoCA as a continuous variable.