Table 2.

Range and discriminative ability of the cumulative 10-year breast cancer risk scores calculated with BOADICEA.

Variables included	Mean % (range)		C-statistic	95% CI
	Unaffected women	BC casesa
Age	3.0 (2.2–3.6)	2.9 (2.2–3.6)	0.531	0.50–0.58
Age, risk factors	2.5 (1.0–5.9)	2.6 (1.4–4.3)	0.558	0.52–0.60
Age, PRS313	3.1 (0.6–11.9)	3.8 (1.2–8.3)	0.636	0.59–0.68
Age, risk factors, PRS313	2.6 (0.4–11.4)	3.3 (0.9–10.5)	0.653	0.60–0.70

BC breast cancer, BOADICEA Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, CI confidence interval, PRS polygenic risk score.

^aWomen who developed BC within 10 years of follow-up.