Figure 8.

Suggested schematic model for WT and acetylation modified Aβ42 peptide aggregation and cytotoxicity. WT Aβ42 and K28Ac peptides show a lag and log phase of aggregation kinetics and form ordered aggregates with large surface hydrophobic patches (yellow) that can assemble as amyloid fibrils and have moderate toxicity. Peptides acetylated at K16 (K16Ac or double acetylated KKAc) show rapid aggregation kinetics and form disordered, amorphous, and flexible aggregates that have higher surface hydrophobicity and high toxicity.