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. 2020 Oct 15;5(20):e140109. doi: 10.1172/jci.insight.140109

Figure 1. 8-Aminoguanine (8-AG) attenuates age-related differences in bladder function.

Figure 1

(A–C) 8-AG decreases voiding frequency (A) (n = young, 13; aged, 21; aged + 8-AG, 30) and increases both the inter-void interval (B) (n = young, 13; aged, 22; aged + 8-AG, 30) and voided volume (C) (n = young, 13; aged, 21; aged + 8-AG, 22). (D and E) In addition, aging decreases abdominal (D) (n = young, 18; aged, 58; aged + 8-AG, 35) and cutaneous (E) (n = young, 13; aged, 21; aged + 8 AG, 23) responses to tactile mechanical stimuli, which is restored to a younger state by 8-AG treatment. Data are presented as mean ± SEM. Ordinary 1-way ANOVA was used to evaluate significance, which was considered at P < 0.05.