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. 2020 Oct 15;5(20):e142446. doi: 10.1172/jci.insight.142446

Figure 5. Ventricular remodeling and dysfunction in D230N hearts is prevented by expression of L48Q cTnC.

Figure 5

Echocardiographic measurements from mice of 2 to 5 months of age reveal that the left ventricular diastolic (A) and systolic (B) inner diameter (LVIDD and LVIDS, respectively) of D230N hearts (blue) progressively increase with age, whereas those of DTG hearts (red) do not change with age and are not significantly different from WT (green) at any age. The fractional shortening (C) and ejection fraction (D) also progressively worsen with age in D230N hearts, whereas those in DTG hearts remain approximately constant and do not significantly differ from WT. * indicates P < 0.05 for D230N vs. WT and + indicates P < 0.05 for D230N vs. DTG using a 1-way ANOVA and a Tukey’s post hoc test of significance. Error bars represent the SEM. See Supplemental Table 3 for all values and sample sizes. cTnC, cardiac troponin C; DTG, double-transgenic.