Figure 3. Male and female FAK^fl/fl Alb-Cre⁺ mice (FAK^–/–) or FAK^fl/fl Alb-Cre^– littermate controls (WT) were aged to 6 months.

(A) Serum liver function tests: aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (Alk Phos). (B) Representative liver H&E and trichrome histology of 6-month-old male WT and FAK^–/– mice. Scale bar: 200 μm. (C) The degree of steatosis as scored by a liver pathologist. For A and C, sample sizes are WT male n = 6, WT female n = 7, FAK^–/– male n = 7, and FAK^–/– female n = 7. Two-way ANOVA was performed with genotype (WT vs. FAK^–/–) and sex (male vs. female) as independent variables; *P < 0.05 by post hoc Tukey’s honestly significant difference test. Data represent individual data points and mean ± SEM.