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. 2020 Oct 15;5(20):e139987. doi: 10.1172/jci.insight.139987

Figure 3. Dose-dependent effect of systemic tail vein administration of TL02-59 on Coll IV microinjection–induced thalamic pain development.

Figure 3

Effect of systemic preadministration of TL02-59 (0 [vehicle], 1, 10, and 15 mg/kg) on paw withdrawal frequencies to 0.07 g (A and E) and 0.4 g (B and F) von Frey filaments and paw withdrawal latencies to heat (C and G) and cold (D) stimuli on days 1 and 3 after thalamic microinjection of Coll IV on the contralateral (A–D) and ipsilateral (E–G) sides. n = 8 mice/group. Two-way ANOVA with repeated measures followed by post hoc Tukey’s test. **P < 0.01 versus the Coll IV plus vehicle group at the corresponding days.