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. 2020 Oct 15;5(20):e139987. doi: 10.1172/jci.insight.139987

Figure 4. Effect of systemic tail vein administration of TL02-59 on Coll IV microinjection–induced thalamic pain maintenance.

Figure 4

TL02-59 (15 mg/kg) or vehicle was given 1 day after Coll IV microinjection and once daily post–Coll IV microinjection for 5 days. Effect of systemic preadministration of TL02-59 or vehicle on paw withdrawal frequencies to 0.07 g (A) and 0.4 g (B) von Frey filaments and paw withdrawal latencies to heat (C) and cold (D) stimuli on days 3 and 5 after thalamic microinjection of Coll IV on the contralateral and ipsilateral sides. n = 8 mice/group. Two-way ANOVA with repeated measures followed by post hoc Tukey’s test. **P < 0.01 versus the corresponding baseline (day –1). ##P < 0.01 versus the Coll IV plus vehicle group at the corresponding days.