Figure 5. Effect of systemic tail vein administration of TL02-59 (15 mg/kg) on Coll IV microinjection–induced thalamic lesion.

(A) Representative coronal brain sections stained with Nissl from the different treatment groups on day 3 after thalamic microinjection of Coll IV or saline. Top: thalamic sections including VPL and VPM. Scale bar: 100 μm. Bottom: magnification of the corresponding top photographs. Scale bar: 50 μm. (B) Number of Nissl-stained cells in the VPL and VPM of thalami from the different treatment groups as indicated. n = 3 biological repeats/group. Two-way ANOVA with repeated measures followed by post hoc Tukey’s test. **P < 0.01 versus the saline plus vehicle–treated group. ^##P < 0.01 versus the Coll IV plus vehicle–treated group.