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. 2020 Oct 15;5(20):e138873. doi: 10.1172/jci.insight.138873

Figure 4. Absence of the Pad2 gene attenuates vascular permeability and ALI in a CLP murine model of sepsis.

Figure 4

WT and Pad2–/– mice were subjected to CLP. (A) Vascular permeability in lung, kidney, spleen, and liver after 24 hours (n = 4/group) as measured by the weight of EB dye in tissue. (B) Representative histology images of murine lungs following H&E staining and (n = 4–5/group). (C and D) ALI score (C) and concentrations of MIP-2, IL-6, and IP-10 (D) in the bronchoalveolar lavage fluid (n = 3-6/group). Data are expressed as mean ± SEM. Data with 2 groups were analyzed using an unpaired 2-tailed Student’s t test (A), and 3 or more groups were analyzed by 2-way ANOVA with Bonferroni’s multiple comparisons test (C and D). *P < 0.05, **P < 0.01, ***P < 0.001. Scale bar: 50 μm.