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. 2020 Oct 29;15:8427–8436. doi: 10.2147/IJN.S272319

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© 2020 Wi et al.

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Therapeutic efficacy of LN-NE-DOX-liposomes in a HeyA8 tumor model. Liposomal formulations were injected intravenously at a dose of 100 mg/kg LN (twice a week) or 5 mg/kg DOX (once a week) based on body weight. (A) Experimental timeline. (B) Tumor weight, (C) tumor nodules, and (D) body weight. (E) Immunohistochemical analyses for cell proliferation (Ki67), microvessel density (CD31), and apoptosis (caspase-3) were performed in HeyA8 tumor tissue (scale bar: 50 μm). (*p < 0.05, **p < 0.01, and ***p < 0.001). The data are presented as the mean ± S.D. (n = 5).