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. 2020 Oct 29;15:8465–8478. doi: 10.2147/IJN.S272571

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© 2020 Zhou et al.

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Evaluation of bone regeneration in calvarial defect through histological staining.

Notes: (A) Representative H&E staining images of MBG/SIS, MBG/SIS-P28 and MBG/SIS-H-P28 groups at 6 and 12weeks. (B) High-magnification image of the black rectangle in A. (C) histomorphometry analysis of percentage of new bone area in the rat cranial defect. Statistical significance is indicated by *p < 0.05 compared with MBG/SIS group and ^#p<0.05 compared with MBG/SIS-P28.

Abbreviations: MBG, mesoporous bioactive glass; SIS, small intestinal submucosa; OB, osteoblast cells.