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. 2020 Oct 29;13:11059–11070. doi: 10.2147/OTT.S235643

Figure 3.

Figure 3

DUXAP8 promoted CRC cell invasion, migration, and EMT. (A) Transwell assays revealed that knockdown of DUXAP8 inhibited the migration of SW620 cells, while overexpression DUXAP8 promoted the migration of LoVo cells. (B) Wound healing assays showed that knockdown of DUXAP8 significantly reduced the wound healing ability of SW620 cells, while its overexpression greatly increased the wound healing ability of LoVo cells. ***P < 0.01, ###P < 0.001. (C) Western blotting was performed to evaluate the levels of E-cadherin, N-cadherin, snail, and vimentin expression after knockdown of DUXAP8 in SW620 cells and overexpression of DUXAP8 in LoVo cells. *P < 0.05, ***P < 0.001. (D) Immunofluorescence studies detected the expression of E-cadherin, N-cadherin, Snail, and Vimentin in DUXAP8 knockdown SW620 cells and DUXAP8 overexpressing LoVo cells.