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. 2020 Nov 2;15(11):e0241751. doi: 10.1371/journal.pone.0241751

Table 4. Proportion meta-analysis of mortality rates in Brazilian studies by time period.

Time period  Studies
n
I2% Events n Patients n Proportion meta-analysis per 10,000 anesthetics (95% CI) P value for subgroup
Pre-1990 versus 1990–2020
Perioperative mortality
Pre-1990 1 NA 99 51,422 19.25 (15.64–23.24) 0.1984
1990–2020 8 99.0 1,054 532,546 25.40 (13.01–41.86)
Anesthesia-related mortality
Pre-1990 1 NA 9 51,422 1.75 (0.76–3.11) 0.5404
1990–2020 6 81.0 20 287,402 0.67 (0.09–1.66)
Entirely anesthesia-related mortality
Pre-1990 - - - - - NA
1990–2020 5 49.1 7 228,849 0.22 (0.05–0.68)

Abbreviations. I2: indicates heterogeneity among studies; CI = confidence interval; NA = not available