Table 2. Multivariate analyses of clinical factor associations with DFS and OS (N = 1,237), showing hazard ratios (HR) with associated confidence intervals (CI) for DFS and OS and their significance for each factor.
| Factors | Groups | Disease-free survival | Overall survival | ||
|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | ||
| Age (years) | ≥ 75/< 75 | 1.42 (1.13–1.77) | 0.0025 | 1.87 (1.44–2.44) | < 0.0001 |
| Sex | Male/Female | 1.82 (1.43–2.32) | < 0.0001 | 2.14 (1.59–2.88) | < 0.0001 |
| Smoking history | Smoked/Never smoked | - | - | - | - |
| Tumor in left or right lung | Right/Left | - | - | - | - |
| Tumor in upper lobe or other | Upper/Others | 0.72 (0.58–0.89) | 0.0021 | - | - |
| Pathological stage | ≥ II/I | 2.68 (2.10–3.41) | < 0.0001 | 2.61 (1.93–3.54) | < 0.0001 |
| Surgical procedure | ≥ Lobectomy/Sublobar resection | - | - | 0.69 (0.49–0.98) | 0.0371 |
| Histology | Sq/Non-Sq | 1.58 (1.22–2.05) | 0.0005 | 2.17 (1.62–2.90) | < 0.0001 |
| Pl | Yes/No | 1.68 (1.31–2.12) | < 0.0001 | 1.33 (1.00–1.78) | 0.0496 |
| Ly | Yes/No | 2.64 (2.01–3.47) | < 0.0001 | 2.21 (1.59–3.07) | < 0.0001 |
| V | Yes/No | 1.41 (1.10–1.81) | 0.0064 | 1.41 (1.05–1.89) | 0.0224 |
| Adjuvant chemotherapy | Yes/No | - | - | - | - |
| Alb (g/dL) | ≥ 3.5/< 3.5 | - | - | - | - |
| CRP (mg/dL) | ≥ 0.3/< 0.3 | - | - | - | - |
| LDH (U/L) | ≥ 222/< 222 | 1.35 (1.05–1.73) | 0.0195 | 1.42 (1.06–1.89) | 0.0187 |
| NLR | ≥ 2.56/< 2.56 | - | - | - | - |
| LMR | ≥ 5.11/< 5.11 | 0.69 (0.55–0.86) | 0.0009 | 0.64 (0.49–0.83) | 0.0008 |
| PLR | ≥ 164/< 164 | - | - | - | - |
Alb, albumin; CRP, C-reactive protein; LDH, lactate dehydrogenase; LMR, lymphocyte-monocyte ratio; Ly, lymphatic invasion; NLR, neutrophil-lymphocyte ratio; Pl, pleural invasion; PLR, platelet-lymphocyte ratio; Sq, squamous cell carcinoma; V, vascular invasion.