Table 1 |.

Unique clinical features in CGL subtypes

Complication	Type 1 CGL	Type 2 CGL	Type 3 CGL	Type 4 CGL
Adipose tissue	Absent metabolically active adipose tissue Preserved mechanical adipose tissue	Absent metabolically active and mechanical adipose tissue	Absent metabolically active adipose tissue Preserved mechanical and bone marrow adipose tissue	Absent metabolically active adipose tissue Preserved mechanical and bone marrow adipose tissue
Cardiovascular complications	N/A	Cardiomyopathy	N/A	Cardiomyopathy Ventricular arrhythmia, extended QT interval and sudden death
Bones, joints and movement	Focal lytic lesions in the long bones after puberty	Spastic gait (rare)	Short stature	Osteopenia, distal metaphyseal deformation with joint stiffness, atlanto-axial instability
Gastrointestinal complications	N/A	N/A	Functional megaoesophagus	Congenital pyloric stenosis
Skeletal muscle	N/A	N/A	N/A	Congenital myopathy
Other features	Acromegaloid features with enlarged mandible, hands and feet	Teratozoospermia	Hypocalcaemia due to vitamin D resistance	Late onset of lipodystrophy in infancy

Abbreviations: CGL, congenital generalized lipodystrophy; N/A, not applicable.