Table 1.

CMV and EBV biology.

	Cytomegalovirus	Epstein-Barr virus	Reference
Family, subfamily, and type	Herpesviridae; Betaherpesvirinae; HHV-5	Herpesviridae; Gammaherpesvirinae; HHV-4	Davison et al. 2005 [15]; Spano et al. 2004 [16]; Bolis et al. 2016 [5]; Santos et al. 2014 [17]; Beltran and Cristea, 2014 [28]; Shabani, Nichols and Rezaei, 2016 [32]; Li et al. 2016 [33]; Landolfo et al. 2003 [18]; Johannsen et al. 2016 [19]; Kalejta, 2008 [22] Mocarski, 2002 [24]; Plachter, Sinzger and Jahn, 1996 [37]; Chen, Jardetzky and Longnecke, 2016 [45]; Oliveira et al. 2012 [2]; Plosa et al. 2012 [38]; Forman et al. 2015 [35]; Hess, 2004 [52];
Genome and genotypes	Linear dsDNA coding more than 200 proteins Four genotypes: gB1, gB2, gB3 and gB4	Linear dsDNA coding for 87 proteins Two genotypes: EBV-1 and EBV-2
Cycle	Three lytic phases: immediate-early (IE), early (E), and late (L)	Latency types 0, I, II and III7 Three lytic phases: immediate-early (IE), early (E), and late (L)
Capsid proteins	pUL46, pUL48.5, minor capsid protein (mCP), major capsid protein (MCP)	MCP, mCP, mCPBP, sCP
Envelope proteins	gpUL55 (gB), gpUL73 (gN), gpUL74 (gO), gpUL75 (gH), gpUL100 (gM) e gpUL115 (gL)	gM, gN, gBC, gBN, gB, gp350, gp150, gp42, gL, gH, gp78
Tegument proteins	38 proteins, including pp28, pp65, pp71, and pp150	LTP, LTPBP, BLRF2, BRRF2, MyrP, MyrPBP, MTP, PalmP, HSP70, BKRF4, BDLF2, and others
Tropism	Salivary glands, macrophage, leukocytes, and can infect endothelial, epithelial, hematopoietic progenitor, peripheral blood mononuclear, smooth muscle, and fibroblast cells	Oral pharynx epithelial cells Lymphocytes, gastric mucosa, smooth muscle cells, and others
Transmission	Body fluids (urine, saliva, tears, milk, blood), genital secretions, transplanted organs, and sexual transmission	Body fluids (saliva, blood, and others), transplantation, and sexual transmission