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. 2020 Sep 29;11(11):3117–3125. doi: 10.1111/1759-7714.13619

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© 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Aspirin with cisplatin inhibited the growth of H460 tumors. Asp, aspirin; Cis, cisplatin; Cont, control. (a) The administration of aspirin with cisplatin significantly inhibited H460R tumor growth. Tumor size in the Asp + Cis group was the smallest while that in control animals was the largest. Tumor sizes in the Asp and Cis group were smaller than that in the Cont group. Tumor sizes after treatment of BALB/c nude female mice with 50 mg/kg aspirin and 30 mg/kg cisplatin. The right panel shows changes in tumor size in each group, and the left panel shows representative images of the tumors. Values are expressed as means ± SD, n = 5; #P < 0.05 versus the Asp, Cis, Asp + Cis groups at the same time point; *P < 0.05 versus Asp + Met groups at the same time point. ^P < 0.05 versus Asp + Met groups at the same time point () Cont, () Asp, () Cis, () Asp+Cis. (b) Apoptosis assayed with TUNEL staining (magnification, x200). The Cont group showed the least apoptosis while the Asp + Cis group showed the most. Values are expressed as means ± SD, n = 3, *P < 0.05. (c) BCL‐2 expression in H460R transplantation tumors with Asp (ES) or Cisplatin (Cis) treatment for 21 days. The positive rate was highest in the Asp + Cis group. *P < 0.05 compared with the Cis group. Values are expressed as means ± SD, n = 3.

Inline graphic — Aspirin with cisplatin inhibited the growth of H460 tumors. Asp, aspirin; Cis, cisplatin; Cont, control. (a) The administration of aspirin with cisplatin significantly inhibited H460R tumor growth. Tumor size in the Asp + Cis group was the smallest while that in control animals was the largest. Tumor sizes in the Asp and Cis group were smaller than that in the Cont group. Tumor sizes after treatment of BALB/c nude female mice with 50 mg/kg aspirin and 30 mg/kg cisplatin. The right panel shows changes in tumor size in each group, and the left panel shows representative images of the tumors. Values are expressed as means ± SD, n = 5; #P < 0.05 versus the Asp, Cis, Asp + Cis groups at the same time point; *P < 0.05 versus Asp + Met groups at the same time point. ^P < 0.05 versus Asp + Met groups at the same time point () Cont, () Asp, () Cis, () Asp+Cis. (b) Apoptosis assayed with TUNEL staining (magnification, x200). The Cont group showed the least apoptosis while the Asp + Cis group showed the most. Values are expressed as means ± SD, n = 3, *P < 0.05. (c) BCL‐2 expression in H460R transplantation tumors with Asp (ES) or Cisplatin (Cis) treatment for 21 days. The positive rate was highest in the Asp + Cis group. *P < 0.05 compared with the Cis group. Values are expressed as means ± SD, n = 3.