Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 30;11(11):3071–3085. doi: 10.1111/1759-7714.13142

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Altered HOXB7 expression in ESCC confers a varied response to cisplatin. (a) HOXB7 expression was detected in a panel of four ESCC cell lines at levels of mRNA and protein. According to the relative expression level, they are sorted as KYSE150 > KYSE180 > KYSE70 > KYSE450. (b) These four ESCC cell lines were treated with gradient concentration of cisplatin (0.25, 0.5, 1, 2, 4, 8,16,32 μg/mL) for 24 hours, and the cell viability was assessed by using the CCK8 assay. It was shown that KYSE450 was most sensitive, with IC50 = 5.051 μg/mL (95%CI 5.902–7.718), and KYSE 150 was relatively resistant, with IC50 = 15.110 μg/mL (95%CI 13.740–16.620). It was considered that a high expression of HOXB7 was associated with cisplatin resistance. This experiment was performed thrice in triplicates. () KYSE 70, () KYSE 150, () KYSE 180, and () KYSE 450.

Inline graphic — Altered HOXB7 expression in ESCC confers a varied response to cisplatin. (a) HOXB7 expression was detected in a panel of four ESCC cell lines at levels of mRNA and protein. According to the relative expression level, they are sorted as KYSE150 > KYSE180 > KYSE70 > KYSE450. (b) These four ESCC cell lines were treated with gradient concentration of cisplatin (0.25, 0.5, 1, 2, 4, 8,16,32 μg/mL) for 24 hours, and the cell viability was assessed by using the CCK8 assay. It was shown that KYSE450 was most sensitive, with IC50 = 5.051 μg/mL (95%CI 5.902–7.718), and KYSE 150 was relatively resistant, with IC50 = 15.110 μg/mL (95%CI 13.740–16.620). It was considered that a high expression of HOXB7 was associated with cisplatin resistance. This experiment was performed thrice in triplicates. () KYSE 70, () KYSE 150, () KYSE 180, and () KYSE 450.