Table 3.

AUC comparison of CAC counts with established tumor biomarkers

NSCLC versus healthy participants	AUC (95% CI)
CAC counts	0.769 (0.716–0.822)
CEA	0.528 (0.456–0.600)
NSE	0.511 (0.438–0.585)
TPSA	0.520 (0.447–0.593)
SCC	0.528 (0.456–0.600)
ProGRP	0.502 (0.428–0.576)
CA19‐9	0.520 (0.447–0.592)
CYFRA21‐1	0.516 (0.442–0.589)
All tumor biomarkers †	0.558 (0.485–0.631)

^†All tumor biomarkers: CEA + NSE + TPSA + SCC + ProGRP + CA19‐9 + CYFRA21‐1.

AUC, area under curve; CA19‐9, carbohydrate antigen 19‐9; CACs, circulating genetically abnormal cells; CEA, carcinoembryonic antigen; CYFRA21‐1, cytokeratin 19 fragment 21‐1; NSCLC, non‐small cell lung cancer; NSE, neuron‐specific enolase; ProGRP, progastrin‐releasing peptide; SCC‐Ag, squamous cell carcinoma antigen; TPSA, total prostate specific antigen.