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. 2020 Sep 14;11(11):3155–3167. doi: 10.1111/1759-7714.13634

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© 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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HAX1 promotes the survival of NSCLC cells via AKT/mTOR signaling pathway. (a) Phosphorylation of AKT, mTOR and 70S6K was inhibited in A549 and H1299 cells transfected with si‐HAX1. (b) Quantitative analysis of protein p‐AKT, p‐mTOR and p‐70S6K expression in A549 and H1299 cells. () A549/si‐NC, () H1299/si‐NC, () A549/si‐HAX1 and () H1299/si‐HAX1. () A549/si‐NC, () H1299/si‐NC, () A549/si‐HAX1 and () H1299/si‐HAX1. () A549/si‐NC, () H1299/si‐NC, () A549/si‐HAX1 and () H1299/si‐HAX1.(c) SC79 promoted the phosphorylation of AKT and mTOR in A549 and H1299 cells transfected with si‐HAX1. (d, e) Quantitative analysis of protein HAX1, p‐AKT, and p‐mTOR expression in A549 and H1299 cells. (f) TUNEL assays for apoptosis of A549 and H1299 cells transfected with si‐HAX1 after treatment of SC79. ***P < 0.001, **P < 0.01, *P < 0.05.

Inline graphic — HAX1 promotes the survival of NSCLC cells via AKT/mTOR signaling pathway. (a) Phosphorylation of AKT, mTOR and 70S6K was inhibited in A549 and H1299 cells transfected with si‐HAX1. (b) Quantitative analysis of protein p‐AKT, p‐mTOR and p‐70S6K expression in A549 and H1299 cells. () A549/si‐NC, () H1299/si‐NC, () A549/si‐HAX1 and () H1299/si‐HAX1. () A549/si‐NC, () H1299/si‐NC, () A549/si‐HAX1 and () H1299/si‐HAX1. () A549/si‐NC, () H1299/si‐NC, () A549/si‐HAX1 and () H1299/si‐HAX1.(c) SC79 promoted the phosphorylation of AKT and mTOR in A549 and H1299 cells transfected with si‐HAX1. (d, e) Quantitative analysis of protein HAX1, p‐AKT, and p‐mTOR expression in A549 and H1299 cells. (f) TUNEL assays for apoptosis of A549 and H1299 cells transfected with si‐HAX1 after treatment of SC79. ***P < 0.001, **P < 0.01, *P < 0.05.