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Design of IDO1 PROTAC degraders. (A) The co-crystal structure of IDO1 (green, PDB: 5WN8) and CRBN (pink, PDB: 5FQD) with their ligand Epa and lenalidomide respectively. Linker was attached via the solvent exposed site. (B) Structure of IDO1 PROTACs based on Epa and CRBN ligands.
