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The structure and small molecule inhibitors of HSP40. (A) The classification of the functional domains of HSP40 (DNAJ). HSP40 could be divided into three subclasses (DNAJA, DNAJB and DNAJC). Each of them is partly consisted of J domain, glycine/phenylalanine-rich region (G/F), cysteine-repeat motif (Cys-rich) and a fully characterized C-terminal domain. (B) Chemical structures of small molecules involving the function of HSP40 inhibition.
