Table 2.

Structures, mechanisms and activities of HSP70 inhibitors.

Name	Year	Structure	Mechanism	In vitro assay	In vivo efficacy	Ref.
VER-155008	2011		ATPase inhibition	Kd = 0.08 μmol/L	Yesa	85, 86, 87, 88, 89, 90, 91, 92
Apoptozole	2015		ATPase inhibition	Low μmol/L	Yes	93
MAL3-101	2004		Disrupt HSP70–HSP40 (allosteric)	Mid to high μmol/L	Yes	94, 95, 96, 97
JG-231	2000		Disrupt HSP70–BAG (allosteric)	EC50 = 0.03 μmol/L	Yes	98, 99
YK5	2014		Allosteric on NBD	Low to Mid μmol/L	NAb	100
HS-72	2014		Allosteric on SBD	Mid μmol/L	Yes	101
PES	2009		Allosteric on SBD	Not reported	Yes	102
Novolactone	2015		Covalently and allosteric on SBD	IC50 = 0.25 μmol/L	NA	103

^aEffective in vivo.

^bNo activity.