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. 2020 Jul 13;10(10):1880–1903. doi: 10.1016/j.apsb.2020.07.003

Table 2.

The functions of cathepsins in necroptosis and pyroptosis.

Content Necroptosis Pyroptosis
Similarities
  • 1.

    Released from lysosome into cytoplasm after lysosomal damage.

  • 2.

    Promote necroptosis or pyroptosis in most cases.
Types involved Mainly: B and D; others: L Mainly: B; others: D, L, and X
Role Downstream executor Upstream trigger
Functions Interact with cytosolic signaling proteins, gradually self-digest certain cellular constituents, enhance LMP, induce mitochondrial and plasma membrane permeabilization, and finally cause cell death.
  • 1.

    Bind to and activate NLRP3 inflammasome, ending up with caspase-1 activation.

  • 2.

    In pyroptosis induced by the endocytosis of HMGB1, cathepsin B release is necessary for pyroptosome formation, culminating in caspase-1 activation.