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Mitochondrial fusion is controlled by outer mitochondrial membrane (OMM)-localized mitofusin 2 (MFN2) and inner mitochondrial membrane (IMM)-localized optic atrophy 1 (OPA1). Increased mitochondrial fusion inhibits mitochondrial fission, sustains mitochondrial potential, promotes mitochondrial bioenergetics and suppresses mitochondrial apoptosis.
