Table 1.
Compounds or drugs targeting mitochondrial quality control (MQC) in cardiac I/R injury.
| Name | Target | Ref. |
|---|---|---|
| Mdivi-1 | Mitochondrial fission (DRP1) | 179,180 |
| Propofol | Mitochondrial fission (DRP1) | 181 |
| Dapagliflozin | Mitochondrial fission (DRP1) | 182 |
| Dynasore | Mitochondrial fission (DRP1) | 183 |
| Isosteviol sodium | Mitochondrial fission (DRP1/FIS1) | 184 |
| Tetrahydrocurcumin | Mitochondrial fission and fusion (DRP1 and MFN2) | 185 |
| Pravastatin | Mitochondrial fission and fusion (DRP1 and MFN1) | 186 |
| Vildagliptin | Mitochondrial fusion (MFN2) | 64 |
| Mitochondrial fusion promoter M1 | Mitochondrial fusion (MFN1/2 and OPA1) | 187 |
| Melatonin | Mitochondrial fusion and mitophagy (OPA1 and FUNDC1) | 79 , 122 |
| Tongxinluo | Mitophagy (PARKIN) | 188 |
| Bicarbonate | Mitophagy (PARKIN) | 189 |
| Simvastatin | Mitophagy (PARKIN) | 190 |
| Ellagic acid | Mitophagy (BNIP3) | 117 |
| Hydrogen-rich saline | Mitophagy (PARKIN) | 191 |
| Metformin | Necroptosis (RIPK1 and RIPK3) | 192 |
| Dexmedetomidine | Necroptosis (RIPK3) | 193 |
| Necrostatin-1 | Necroptosis (RIPK1) | 194 |
| Baicalin | Necroptosis (RIPK3 and MLKL) | 195 |
| Ciclosporin A | Necroptosis (mPTP opening) | 167 |
| Tanshinone IIA | Apoptosis (BAX/BCL2) | 196 |
| Taxifolin | Apoptosis (BAX/BCL2) | 197 |
| Glutamine | Apoptosis (Cyt-c) | 198 |
| Febuxostat | Apoptosis (Cyt-c) | 199 |
| PD150606 | Apoptosis (Cyt-c) | 42 |
| Ru360 | Apoptosis (BAX) | 200 |