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. 2019 Jun 26;10(10):1977–1988. doi: 10.1016/j.apsb.2019.06.008

Figure 4.

Figure 4

Biodistribution of GLT in vivo. (A) In vivo images of mice and (B) semiquantitative mean fluorescence intensity results showing the tumor distribution of DiD in 4T1 tumor-bearing mice at 1, 2, 4, 8, 12 and 24 h (mean ± SD, n = 3; ∗P＜0.05,∗∗P＜0.01 and ∗∗∗P＜0.001). (C) In vitro images of organs and (D) semiquantitative mean fluorescence intensity results showing the organ distribution of DiD in 4T1 tumor-bearing mice at 24 h (mean ± SD, n = 3; ∗P＜0.05,∗∗P＜0.01 and ∗∗∗P＜0.001). (E) In vitro images of tumors and (F) semiquantitative mean fluorescence intensity results showing the tumor distribution of DiD at 24 h (mean ± SD, n = 3; ∗P＜0.05,∗∗P＜0.01 and ∗∗∗P＜0.001). (G) CLSM images of tumor tissue frozen sections from 4T1 tumor-bearing mice 24 h after systemic administration of DiD (red). Cell nucleuses were stained with DAPI (blue). Scale bar indicates 200 μm.