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. 2019 Jun 26;10(10):1977–1988. doi: 10.1016/j.apsb.2019.06.008

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© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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In vivo 4T1 solid tumor treatment. (A) Images of 4T1 tumors harvested from BALB/c mice after treatment with PBS, LMWH, free GEM, GTT or GLT, respectively, by intravenous injection. (B) Tumor volume changes in 4T1 tumor-bearing BALB/c mice during the therapies (means ± SD, n = 6; ^∗P＜0.05,^∗∗P＜0.01 and ^∗∗∗P＜0.001). (C) Weights of the harvested 4T1 tumors (means ± SD, n = 6; ^∗P＜0.05,^∗∗P＜0.01 and ^∗∗∗P＜0.001). (D) Expression of MMP-9 in 4T1 tumors tested by Western blot assay. (E) Hematoxylin and eosin (HE) assays for 4T1 tumors (the scale bar represents 100 μm) and immunohistochemical analysis of MMP-9 staining for 4T1 tumors (the scale bar represents 25 μm). The secreted MMP-9 was stained violet and indicated by black arrows.