Table 2:
Individual Characteristics of Patients Who Received allo-HSCT after CAR T cells
| Age at HSCT | Prior allo-HSCT | Disease status | Conditioning Regimen | Time from CAR T cells to allo-HSCT | Graft Source | Graft manipulation | Donor | GVHD ppx | Neutrophil engraftment | Platelet engraftment | Relapse | Cause of Death | Transplant Complications | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 13 | no | CR2 | TBI/thio/cy | 39 | BM | CD34+ | Unrelated 9/10 | TCD | 14 | 215 | No | NA | aGVHD (grade 2) |
| 2 | 16 | yes | CR3 | TBI/thio/cy | 57 | PBSC | CD34+ | Related 10/10 | TCD | 11 | 16 | Yes | NA | None |
| 3 | 12 | no | CR2 | TBI/cy | 57 | BM | Unmodified | Related | Tacro/MMF | 16 | 26 | No | NA | aGVHD (grade 2), cGVHD (*) |
| 4 | 1 | no | CR1 | Clo/mel/thio | 30 | PBSC | CD34+ | Unrelated 9/10 | TCD | 12 | 34 | No | NA | None |
| 5 | 4 | no | CR1 | TBI/thio/cy | 46 | PBSC | CD34+ | Unrelated 9/10 | TCD | 15 | 217 | No | NA | cGVHD (score 3) |
| 6 | 11 | no | CR1 | TBI/thio/cy | 57 | PBSC | CD34+ | Unrelated 10/10 | TCD | 11 | 34 | No | NA | cGVHD (score 1) |
| 7 | 4 | no | CR2 | TBI/thio/cy | 55 | BM | Unmodified | Related 10/10 | Tacro/MTX | 13 | 32 | No | NA | None |
| 8 | 8 | no | CR2 | TBI/thio/cy | 66 | BM | Unmodified | Related 10/10 | Tacro/MTX | 13 | 30 | No | NA | None |
| 9 | 20 | no | CR3 | TBI/cy | 81 | BM | Unmodified | Unrelated 10/10 | CSA/MTX | 23 | 265 | No | GVHD | aGVHD (grade 3), cGVHD (score 3) |
| 10 | 5 | no | CR1 | TBI/thio/cy | 44 | PBSC | CD34+ | Unrelated 10/10 | TCD | 11 | 16 | Yes | NA | None |
| 11 | 13 | no | CR1 | TBI/flu/cy | 64 | BM | Unmodified | Related haplo | Post-cy Tacro/MMF |
29 | NA | No | VOD, MSOF | aGVHD (grade 4), VOD |
| 12 | 15 | no | CR2 | Clo/mel/thio | 45 | PBSC | CD34+ | Related 10/10 | TCD | 11 | 17 | No | NA | None |
| 13 | 20 | no | CR1 | TBI/thio/cy | 135 | PBSC | CD34+ | Related 10/10 | TCD | 9 | 17 | Yes | NA | aGVHD (grade 2) |
| 14 | 18 | yes | CR4 | Flu/mel/thio | 95 | BM | Unmodified | Unrelated 10/10 | Tacro/MTX | 22 | NA | No | VOD, MSOF | VOD |
| 15 | 15 | no | CR3 | TBI/thio/cy | 65 | PBSC | CD34+ | Related 10/10 | TCD | 10 | 26 | No | NA | None |
CAR, chimeric antigen receptor; allo-HSCT, allogeneic hematopoietic stem cell transplantation; CR, complete remission; TBI, total body irradiation; flu, fludarabine; cy, cyclophosphamide; mel, melphalan; thio, thiotepa; clo, clofarabine; BM, bone marrow; PBSC, peripheral blood stem cell; GVHD, graft-vs-host disease; CSA, cyclosporine; MTX, methotrexate; TCD, T cell depleted; tacro, tacrolimus; MMF, mycophenolate mofetil; post cy, post-transplant cyclophosphamide; VOD, veno-occlusive disease; MSOF, multi-system organ failure; aGVHD, acute graft-vs-host disease; cGVHD, chronic graft-vs-host disease.
*
information not available