Table 4.
Relationship between liver injury pattern and disease progress.
| Variables | No liver injury (n = 409) | Hepatocellular pattern (n = 48) | Cholestatic pattern (n = 170) | Mixed pattern (n = 211) | P1 | P2 | P3 |
|---|---|---|---|---|---|---|---|
| n (%) or median (IQR) | n (%) or median (IQR) | n (%) or median (IQR) | n (%) or median (IQR) | ||||
| D-dimer (mg/L) | 0.43 (0.23–0.98) | 0.83 (0.42–2.62) | 0.85 (0.43–4.94) | 0.72 (0.41–2.33) | *** | *** | *** |
| International normalized ratio | 0.98 (0.93–1.06) | 0.99 (0.94–1.06) | 1.01 (0.94–1.13) | 1.00 (0.93–1.09) | 0.495 | ** | 0.088 |
| C-reactive protein (mg/L) | 10.6 (2.9–41.8) | 40.8 (14.2–102.1) | 46.4 (8.9–104.9) | 39.2 (8.0–79.6) | *** | *** | *** |
| Procalcitonin (ug/L) | 0.05 (0.04–0.09) | 0.12 (0.05–0.41) | 0.09 (0.05–0.23) | 0.09 (0.05–0.23) | *** | *** | *** |
| Ferritin (ug/L) | 281.3 (129.0–567.4) | 1171.8 (601.8–2000.0) | 636.5 (351.9–1543.7) | 579.8 (284.1–1257.8) | *** | *** | *** |
| Cardiac injury | 18 (4.4) | 12 (25.0) | 32 (18.8) | 33 (15.6) | *** | *** | *** |
| Kidney injury | 8 (2.0) | 5 (10.4) | 10 (5.9) | 5 (2.4) | ** | * | 0.771 |
| Systemic inflammatory response syndrome | 79 (19.3) | 19 (39.6) | 47 (27.6) | 48 (22.7) | *** | * | 0.316 |
| Severe | 45 (11.0) | 23 (47.9) | 50 (29.4) | 68 (32.2) | *** | *** | *** |
| Deceased | 25 (6.1) | 12 (25.0) | 48 (28.2) | 47 (22.3) | *** | *** | *** |
P1, Hepatocellular pattern vs. no liver injury; P2, Cholestatic pattern vs. no liver injury; P3, Mixed pattern vs. no liver injury.
*
P < 0.05,
**
P < 0.01,
***
P < 0.001. IQR, interquartile range.