Fig. 2.

TFs cooperate with Foxp3 to activate Treg genes or repress non-Treg genes. Increasing number of TFs have been reported to cooperate with Foxp3 to regulate target gene expression. Some of them (e.g., TCF1, Foxp1 and Bcl11b) have been found to co-occupy with Foxp3 onto the target genes. Others (e.g., GATA1, Runx1) are reported to promote Foxp3’s transcriptional activity to either induce the expression of Treg genes (such as Icos, Ctla4) or repress non-Treg genes (such as Il2, Ifng). Changes of Foxp3 domains may alter the interactions between Foxp3 and other TFs (such as IRF4, Eos and HIF1α). TFs that have been reported to have physical interactions with Foxp3 on the protein level are marked in blue