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. 2020 Apr 29;77(21):4269–4287. doi: 10.1007/s00018-020-03534-7

Table 1.

NF-kB family TFs in Treg biology

Name Key role Mechanism References
c-Rel Thymic Treg development [84]
Maintain Foxp3 expression Binding to Foxp3 CNS2, or promoter [81, 83]
Induce Foxp3 expression Binding to Foxp3 CNS3 [81]
RelA Promote eTreg differentiation Form protein–protein complex with NF-κB1 (Ref. [89]) [87, 89, 90]
Treg stability [87, 88, 90]
NF-κB1 Dispensable for Treg cell development [91]