Table 1.
Name | Key role | Mechanism | References |
---|---|---|---|
c-Rel | Thymic Treg development | [84] | |
Maintain Foxp3 expression | Binding to Foxp3 CNS2, or promoter | [81, 83] | |
Induce Foxp3 expression | Binding to Foxp3 CNS3 | [81] | |
RelA | Promote eTreg differentiation | Form protein–protein complex with NF-κB1 (Ref. [89]) | [87, 89, 90] |
Treg stability | [87, 88, 90] | ||
NF-κB1 | Dispensable for Treg cell development | [91] |