TABLE 2.
IC50 values (nM) for nisin A, nisin H, and nisin H F1I with the corresponding fold of resistance (FR) against the strains NZ9000Cm, NZ9000NisI, NZ9000NisFEG, NZ9000SaNSR, and NZ9000SaNsrFP.
| Variant | NZ9000Cm |
NZ9000NisI |
NZ9000NisFEG |
NZ9000SaNSR |
NZ9000SaNsrFP |
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| IC50 | FR | IC50 | FR | IC50 | FR | IC50 | FR | ||
| Nisin A | 4.8 ± 0.7 | 48.6 ± 6.3 | 10.1 ± 2.0 | 53.0 ± 4.5 | 11.1 ± 1.9 | 73.0 ± 3.6 | 15.2 ± 2.5 | 82.1 ± 3.1 | 17.1 ± 2.7 |
| Nisin H | 5.3 ± 1.0 | 43.2 ± 8.7 | 8.1 ± 2.2 | 23.4 ± 3.3 | 4.4 ± 1.0 | 52.4 ± 9.9 | 9.8 ± 2.6 | 86.4 ± 4.1 | 16.2 ± 3.1 |
| Nisin H F1I | 14.2 ± 0.2 | 34.1 ± 0.3 | 2.4 ± 0.1 | 32.1 ± 0.8 | 2.3 ± 0.1 | 44.2 ± 1.3 | 3.1 ± 0.1 | 50.2 ± 1.6 | 3.5 ± 0.1 |