Table 1.
Receptor | Ligand | Most fungal species |
---|---|---|
TLR1/2 | Triacylated lipoprotein | A. fumigatus, C. albicans |
GXM | C. neoformans | |
TLR2 | Phospholipomannan | C. albicans |
β-1,2-oligomannoside | C. albicans, S. schenkii, S. brasiliensis, P. brasiliensis | |
TLR2/6 | Diacylated lipoprotein | A. fumigatus, C. albicans |
GXM | C. neoformans | |
TLR3 | dsRNA | A. fumigatus, P. brasiliensis, C. neoformans |
TLR4 | O-linked mannosyl, mannan | C. albicans, S. serevisiae, S. brasiliensis, P. brasiliensis |
GXM | C. neoformans | |
TLR7 | ssRNA | C. albicans |
TLR8 | ssRNA | C. albicans |
TLR9 | DNA | A. fumigatus, C. neoformans, Candida, P. brasiliensis, M. furfur |
Dectin-1 | β-1,3-glucans | A. fumigatus, C. albicans, P. carinii, S. schenckii, F. pedrosoi, C. neoformans, P. brasiliensis, H. capsulatum, Malassezia spp, S. cerevisiae, C. posadasii, T. mentagrophytes, F. solani, C. cladosporioides |
Dectin-2 | High-mannose structures α-mannans | C. albicans, C. glabrata C. neoformans, T. rubrum, Malassezia spp, H. capsulatum, F. pedrosoi, A. fumigatus and M. audouini |
Dectin-3 | GXM | C. neoformans serotype AD (C.n-AD) and C. gattii serotype B |
α-mannans | C. albicans | |
Mannose receptor | α-glucans | P. brasiliensis, C. yeast, C. neoformans Histoplama capsulatum, Blastomyces dermatitidis |
Chitin | Candida yeast, C. neoformans | |
Mananas | A. fumigatus, S. cerevisiae, P. carinii, C. neoformans, P. brasiliensis, C. albicans, C. parapsilosis, and S. schenckii | |
DC-SIGN | N-linked mannans | Dermatophytes, A. fumigatus, S. cerevisiae, C. neoformans, C. albicans, and C. topicum |
Galactomannans | A. fumigatus | |
MINCLE | a-mannose, glyceroglycolipid | A. fumigatus, Malassezia spp., F. pedrosoi, P. carinii, and C. albicans |
mannosyl fatty acids | Malassezia spp P. carinii | |
MSG/gpA | P. carinii | |
Langerin | β-1,3-glucans | M. furfur, S. cerevisia, C. albicans, C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis |
Galectin-3 | a-mannosides | C. albicans |
GXM, Glucuronoxylomannan; dsRNA, Double-stranded RNA; ssRNA, Single-stranded RNA; MSG/gpA, glycoprotein of P. carinii.