Skip to main content
. 2020 Oct 20;10:591970. doi: 10.3389/fcimb.2020.591970

Table 1.

List of PRRs, their ligands, and respective fungi.

Receptor Ligand Most fungal species
TLR1/2 Triacylated lipoprotein A. fumigatus, C. albicans
GXM C. neoformans
TLR2 Phospholipomannan C. albicans
β-1,2-oligomannoside C. albicans, S. schenkii, S. brasiliensis, P. brasiliensis
TLR2/6 Diacylated lipoprotein A. fumigatus, C. albicans
GXM C. neoformans
TLR3 dsRNA A. fumigatus, P. brasiliensis, C. neoformans
TLR4 O-linked mannosyl, mannan C. albicans, S. serevisiae, S. brasiliensis, P. brasiliensis
GXM C. neoformans
TLR7 ssRNA C. albicans
TLR8 ssRNA C. albicans
TLR9 DNA A. fumigatus, C. neoformans, Candida, P. brasiliensis, M. furfur
Dectin-1 β-1,3-glucans A. fumigatus, C. albicans, P. carinii, S. schenckii, F. pedrosoi, C. neoformans, P. brasiliensis, H. capsulatum, Malassezia spp, S. cerevisiae, C. posadasii, T. mentagrophytes, F. solani, C. cladosporioides
Dectin-2 High-mannose structures α-mannans C. albicans, C. glabrata C. neoformans, T. rubrum, Malassezia spp, H. capsulatum, F. pedrosoi, A. fumigatus and M. audouini
Dectin-3 GXM C. neoformans serotype AD (C.n-AD) and C. gattii serotype B
α-mannans C. albicans
Mannose receptor α-glucans P. brasiliensis, C. yeast, C. neoformans Histoplama capsulatum, Blastomyces dermatitidis
Chitin Candida yeast, C. neoformans
Mananas A. fumigatus, S. cerevisiae, P. carinii, C. neoformans, P. brasiliensis, C. albicans, C. parapsilosis, and S. schenckii
DC-SIGN N-linked mannans Dermatophytes, A. fumigatus, S. cerevisiae, C. neoformans, C. albicans, and C. topicum
Galactomannans A. fumigatus
MINCLE a-mannose, glyceroglycolipid A. fumigatus, Malassezia spp., F. pedrosoi, P. carinii, and C. albicans
mannosyl fatty acids Malassezia spp P. carinii
MSG/gpA P. carinii
Langerin β-1,3-glucans M. furfur, S. cerevisia, C. albicans, C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis
Galectin-3 a-mannosides C. albicans

GXM, Glucuronoxylomannan; dsRNA, Double-stranded RNA; ssRNA, Single-stranded RNA; MSG/gpA, glycoprotein of P. carinii.