Table 4.
Response induced by TLR9 activation.
| Disease | Effect | Outcome |
|---|---|---|
| Systemic candidiasis | IL-12p40 production, CD40 expression and NF- κB activation by BMDCs No effect in BMDM on their antifungal effector functions |
No effect |
| Aspergillosis | Increase of TNF-α and IL-12 cytokine production by both BMDCs and human plasmacytoid dendritic cells No effect in PMN |
Susceptibility |
| Paracoccidioidomycosis | Expression of cytokines and promoting phagocytic capacity in BMDM The combination of CPG and rPb27 induces 98% reduction in fungal burden |
Protective response |
BMDC, bone marrow-derived dendritic cells; PMN, polymorphonuclear; BMDM, bone marrow-derived macrophage; CPG, nomethylated cytosine-guanosine; rPb27, recombinant protein from P. brasiliensis.