Figure 6.
Apatinib inhibited the growth of colorectal cancer cells in vivo. 2 × 106 CT26 cells were transplanted subcutaneously into the armpit of the BALB/c mice. Three days after transplanted, mice were randomly allocated to either control or treatment groups, with 6 mice per group. Drugs were intraperitoneal injected (see in Materials and methods). Bodyweight and tumor volumes were measured every two days (A and D). After mice were sacrificed, solid tumors were separated and weighted (B and C). Data are expressed as means ± SEM, n=8. *P < 0.05, **P < 0.01 vs control group.