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. 2020 Oct 29;13:11031–11044. doi: 10.2147/OTT.S266549

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© 2020 Cai et al.

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Illustration for the mechanism underlying apatinib induced colorectal cancer growth inhibition. By inhibiting VEGFR2-β-catenin mediated singling for colorectal cancer proliferation, invasion, migration and VEGFR2-mediated angiogenesis, apatinib successfully suppressed colorectal cancer growth, suggesting the utility of apatinib as an effective therapeutic strategy for colorectal cancer in the clinic.