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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Trends Cancer. 2020 Jun 11;6(11):924–941. doi: 10.1016/j.trecan.2020.05.010

Figure 1. Essential Enzymes of the mitotic expression module are ideal targets for highly specific mitotic inhibitors.

Figure 1.

Systematic interrogation of the genes associated with the mitotic expression module [48] via CRISPR and RNAi drop-out screening via DepMap reveals essential cell cycle genes. Only proteins which were determined to be druggable are included. Proteins found to be common essential in 100% of the cancer cell lines included in DepMap are indicated in red while those found to be common essential in >95% of cancer cell lines are indicated in purple. An extended list of cell cycle-specific genes with essentiality scores can be found in Supplementary Tables I and II. Note that these lists include the accepted HUGO gene names used at the time of publication.