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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2020 Jul 4;180:114137. doi: 10.1016/j.bcp.2020.114137

Fig. 1.

Fig. 1.

Differential cytotoxicity of LY3023414 in drug-sensitive cells and multidrug-resistant cells overexpressing either ABCB1 or ABCG2. The cytotoxicity of LY3023414 (final DMSO concentration 0.5% (v/v)) in (A) drug-sensitive human OVCAR ovarian cancer cell line (open circles) and its ABCB1-overexpressing variant NCI-ADR-RES (filled circles); (B) drug-sensitive human KB-3–1 epidermal cancer cell line (open circles) and its ABCB1-overexpressing KB-V-1 (filled circles); (C) drug-sensitive human S1 colon cancer cell line (open circles) and its ABCG2-overexpressing S1-M1-80 (filled circles); (D) drug-sensitive human H460 lung cell line (open circles) and its ABCG2-overexpressing H460-MX20 (filled circles); (E) parental pcDNA-HEK293 cells (open circles), HEK293 cells transfected with human ABCB1 (MDR19-HEK293, filled circles) and HEK293 cells transfected with human ABCG2 (R482-HEK293, open squares) was determined over a period of 72 h as described in Materials and methods. Representative immunoblots of ABCB1 and ABCG2 are shown in insets. Points, mean values from at least three independent experiments; bars, SEM.